Welcome to the Systems Biology Laboratory at the University of Melbourne.
At the Systems Biology Lab we build and analyse mathematical models of biological processes, pathways and networks, and the cellular geometries within which these processes take place. We apply these models to problems in human health and physiology, including heart disease, cancer, nanomedicine and synthetic biology.
We are based in the School of Mathematics and Statistics and in the Department of Biomedical Engineering at the University of Melbourne.
We are also part of the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology.
For more information contact Lab Director Professor Edmund Crampin
Congratulations to Matt Faria, who has been awarded his PhD at the Systems Biology Lab and the Caruso group at the University of Melbourne, for his thesis entitled “Quantifying interactions between nanoengineered particles and cells”.
In his thesis, Matt introduced new techniques for quantifying interactions between engineered nanomaterials and biological cells. Using a combination of experimental approaches and mathematical methods, his work isolated the kinetics of cell-particle interactions independent of experimental details.
Well done Matt!
Michael Pan, Hilary Hunt, Claire Miller and Shourya Ghosh all presented their work at the recent Biophysical Society Annual Meeting in San Francisco. Well done all!
Congratulations to Greg Bass, who has been awarded his PhD for his thesis entitled “Decoding calcium signalling crosstalk in cardiac hypertrophy”. Greg investigated calcium signalling in heart muscle cells using imaging data and mathematical models. He showed that two distinct messages can be conveyed simultaneously by modifying the shape of the calcium curve, providing clues for how calcium signals may be encoded and decoded in many cell types.
Well done Greg!
Congratulations to our colleague and former team member Dr Kenneth Tran, from the University of Auckland who, along with Dr Andrew Taberner and Prof Edmund Crampin, has been awarded a grant from the Marsden Fund (Royal Society of New Zealand) to develop a model of heart failure in diabetes.
RSNZ Marsden fund announcement is here.
We are delighted to welcome postdoctoral research fellows Dr Agnė Tilūnaitė and Dr Pete Cudmore to the Systems Biology Lab!
We are pleased to announce successful ARC Linkage Infrastructure, Equipment and Facilities (LIEF) funding worth $639,369 to a team from the ARC Centre of Excellence in BioNano Science, including SBL Director Professor Edmund Crampin. The funding will support a nano-bioscience imaging facility. This project aims to investigate the interactions between nano-engineered materials and biological systems through the use of cutting-edge imaging technologies, including an ImageStreamX Imaging Flow Cytometer and a Coherent Anti-Stokes Raman Scattering Microscope. Together these will allow high throughput and label-free imaging of cell-nanomaterial interactions.
Further details in the announcement here.