Category Archives: Uncategorized

Reference environments: A universal tool for reproducibility in computational biology

Reproducibility of scientific results, or lack thereof, has received increasing attention over recent years. Computational studies, by their nature, should be amongst the most reproducible. However it often proves to be a challenge to reproduce computational results, even when code … Continue reading

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A thermodynamic framework for modelling membrane transporters – published in Journal of Theoretical Biology

Membrane transporters are proteins which facilitate the entry and exit of molecules into cells. Transport processes often require a source of energy in order to move substances against unfavourable concentration gradients or, in the case of charged species, against electrochemical … Continue reading

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Minimum information reporting in bio-nano experimental literature – published in Nature Nanotechnology

Our new paper setting out minimum information criteria for bio-nano research has been published in Nature Nanotechnology. Nature Nanotechnology 13, 777–785 (2018) Download the paper here. Read the Nature Nanotechnology editorial about our work here. This work, led by Matt Faria, has … Continue reading

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Our paper on size dependence of nanoparticle transport – published in Interface

Our new paper on quantifying the influence of the distribution of nanoparticle size (‘polydispersity’) on delivered cellular dose has just appeared in Journal of the Royal Society Interface. S.T. Johnston, M. Faria, E.J. Crampin (2018) An analytical approach for quantifying … Continue reading

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Cell Systems paper on combinatorial miRNA regulation of EMT – now published

Joe’s paper on combinatorial targeting by miRNAs in regulating phenotype in breast cancer cells has appeared in Cell Systems. Micro-RNAs are known to play important roles in driving switching between epithelial and mesenchymal phenotypes in cancer. In the paper we … Continue reading

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Are you coming to SMB2018 in Sydney?

Come and hear about our latest research – all on Monday! Hilary Hunt’s talk on cardiac hypertrophy signalling is at 1130am; Claire Miller’s talk on multicellular modelling of the epidermis is at 4pm; and Stuart Johnston’s talk on nanoparticle delivery … Continue reading

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Bond graph modelling of the cardiac action potential – published in Proceedings of the Royal Society A

Our paper on modelling the cardiac action potential using an energy-based bond graph approach has now appeared in Proc R Soc Lond A. Mathematical models of cardiac action potentials have become increasingly important in the study of heart disease and … Continue reading

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