Professor Edmund Crampin
Edmund is Rowden White Chair of Systems Biology, Chair of the Computational Biology Research Initiative and Director of the Systems Biology Lab at the University of Melbourne. He studied physics at Imperial College London and obtained a DPhil in mathematical biology at the University of Oxford, where he also held a Junior Research Fellowship. Edmund was previously Associate Professor and Group Leader at the Auckland Bioengineering Institute at the University of Auckland, New Zealand. Edmund’s research interests are in mathematical modelling of cellular processes and pathways underlying human disease. Current projects include modelling heart cells to understand the development of heart disease; computational approaches to study the network of genetic interactions underlying cancer; mathematical modelling in nano medicine and drug delivery; and development of modelling approaches, computational tools and standards for integrative systems biology.
More about Edmund
Professor Peter Gawthrop
Peter is a Professorial Fellow in the Department of Biomedical Engineering at the University of Melbourne, and Emeritus Professor of Control Engineering at the University of Glasgow. Peter obtained his BA (Hons), DPhil and MA degrees in Engineering Science from the University of Oxford, and previously held the Wylie Chair of Control Engineering at Glasgow University. He is a Fellow of the Institution of Engineering and Technology, and the Institution of Mechanical Engineers. Peter’s current research interests include developing intermittent control theory as a new paradigm for engineering and physiological control, and application of bond graphs in systems biology to model the network thermodynamics of biochemical systems.
Dr Vijay Rajagopal
Vijay is Senior Lecturer in the Department of Biomedical Engineering, and leads the Cell Structure and Mechanobiology Group. He completed his PhD in Bioengineering at the Auckland Bioengineering Institute, University of Auckland, in 2007, focusing on the development of computational models of breast tissue mechanics to aid breast cancer diagnostic procedures. He subsequently developed expertise in experimental and computational cellular mechanics in Auckland and at the Singapore-MIT Alliance for Research and Technology, prior to moving to the University of Melbourne.
Vijay’s group website
Dr Daniel Hurley (Senior Research Fellow)
Model reproducibility and reuse in computational biology
Daniel completed his BSc, MSc and PhD degrees at the University of Auckland. His research focuses on techniques for regulatory network inference from large-scale transcriptomic and proteomic data, and application of those techniques to drive the formulation and testing of experimental hypotheses. Before returning to research, his career was in commercial IT, with emphasis on project management for software development, software consultancy and technical communication.
Dr Peter Cudmore (Research Fellow)
Modelling and design for synthetic biology
Peter completed his PhD in Mathematics at the University of Queensland where he developed new results regarding the emergence of stable macroscopic oscillations in a weakly heterogeneous populations of nonlinearly coupled oscillators. Peter’s current project involves using bond graph methods to advance modelling, design and control of synthetic biological systems.
Dr Stuart Johnston (Research Fellow)
Mathematical modelling of bio-nano interactions
Stuart completed his PhD in Applied Mathematics at the Queensland University of Technology in 2017, during which he investigated models of collective cell behaviour and techniques for interfacing these models with experimental data. Stuart’s current focus is on developing methods for investigating the influence of nanoparticle polydispersity on nanoparticle-cell interactions and modelling cellular uptake pathways.
Dr David Ladd (Research Fellow)
Computational cell modelling for bio-nano interactions
David completed his PhD in Bioengineering at the Auckland Bioengineering Institute, University of Auckland, working on multiscale modelling methods for arterial fluid mechanics. His current project focuses on computational approaches for cell modelling, in particular using imaging data, and applying these approaches to develop frameworks that link computational models and related experimental data.
Dr Agne Tilunaite (Research Fellow)
Cardiac cell systems biology
Agne completed her PhD in Mathematics at the University of Nottingham, during which she used a range of mathematical techniques to explore how non-excitable cells react to time dependent stimulations of agonists. The aim of Agne’s current project is to develop biophysically realistic and structurally detailed mathematical models of calcium signalling in heart cells.
Mathematical modelling of bio-nano interactions
Cosupervised with Professor Frank Caruso (Chemical Engineering)
Matt graduated with a BSc (Computer Science) from Carnegie Mellon University. Matt’s research is on computational modelling of the interactions between nanoparticles and biological systems, in collaboration with the Nanostructured Interfaces and Materials Science Group lead by Professor Frank Caruso.
A bond graph approach to integrative biophysical modelling
Cosupervised with Professor Peter Gawthrop and Dr Joe Cursons (Bioinformatics, WEHI)
Michael completed his Bachelor of Biomedicine and Master of Engineering (Biomedical) at the University of Melbourne. He is using bond graph theory to develop methods for coupling biophysical models, with a focus towards cardiac cell modelling.
Calcium signalling in cardiac hypertrophy
Cosupervised with Dr Vijay Rajagopal
Following a Bachelor of Philosophy (Science) at the Australian National University, Hilary is now developing models of intracellular calcium signals involved in the development of heart disease.
Multiscale modelling of the epidermis
Cosupervised with Dr James Osborne (School of Mathematics and Statistics)
Claire completed her undergraduate degree in Computational and Mechanical Engineering (Hons) at the University of Adelaide. She started her PhD in early 2016 and is interested in using multi-cellular and sub-cellular models to understand how the developed epidermis maintains structure in homeostasis.
The role of ultrastructural alterations in diabetic cardiomyopathy
Cosupervised with Dr Vijay Rajagopal
Shourya completed a Bachelor of Technology (Hons) from the Indian Institute of Technology Bhubaneswar. Shourya is using a combination of Electron Microscopy and Finite Element Analysis to study the spatial distribution of mitochondria in cardiac myocytes and how this distribution changes in disorders such as diabetes.
Cancer systems biology
Cosupervised with Dr Melissa Davis (Bioinformatics, WEHI)
Greg Bass (PhD 2018)
Decoding calcium signalling crosstalk in cardiac hypertrophy
Cosupervised with Dr Vijay Rajagopal, Greg investigated calcium signalling in heart muscle cells using imaging data and mathematical models. He showed that two distinct messages can be conveyed simultaneously by modifying the shape of the calcium curve, providing clues for how calcium signals may be encoded and decoded in many cell types. Greg has now taken up a position at CSL Ltd.
David Budden (PhD 2017)
The Systems Biology of Eukaryotic Transcription
Cosupervised with Dr Melissa Davis (Bioinformatics, WEHI), David’s research involved modeling the regulation of gene expression using machine learning and information-theoretic approaches, with particular focus on the interactions and feedback mechanisms between transcription factors, histone modifications and microRNAs in cancer.
Following a Postdoctoral Fellowship at MIT, David took took up a role as Research Engineer at DeepMind.
Joe Cursons (Research Fellow 2012-2016)
Joe completed his PhD and a postdoctoral fellowship in the Systems Biology Lab. Joe’s PhD work considered ERK-MAPK signalling in situ in the epidermis (skin) from both experimental and modelling perspectives, while his postdoctoral work focused on analysis of transcriptional datasets in cancer.
Joe is currently a Research Fellow at the Walter and Eliza Hall Institute (WEHI) in Melbourne.
Ivo Siekmann (Research Fellow 2009-2015)
Ivo’s research focused on mathematical analysis and modelling of ion channel data, specifically the IP3-Receptor. Ivo’s work uncovered a new ‘modal’ model to explain the dynamical behaviour of the channel.
Ivo is currently Lecturer in Applied Mathematics at Liverpool John Moores University.
Melissa Davis (Senior Research Fellow 2013-2015)
Melissa is currently laboratory head and group leader in the Bioinformatics division at WEHI. She holds a BSc (Genetics) and a PhD from the University of Queensland. Melissa’s research is focused on the systems biology of epithelial-mesenchymal plasticity in breast cancer. Melissa specialises in the integration of genomic, transcriptomic, and proteomic data with knowledge-based network models to identify sub-networks and pathways disrupted in cancer.
Jerry Gao (Research Fellow 2014-2015)
Following a postdoctoral position at the Walter and Eliza Hall Institute (WEHI) in Melbourne, Jerry took up a role as a Quantitative Analyst at the Future Fund Management Agency.